Comparative proteomic analysis of human peripheral blood mononuclear cells indicates adaptive response to low-dose radiation in individuals from high background radiation areas of Kerala
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چکیده
منابع مشابه
Quantitation of genome damage and transcriptional profile of DNA damage response genes in human peripheral blood mononuclear cells exposed in vitro to low doses of neutron radiation
Background: Humans are exposed to ionizing radiation from different sources that include natural, occupational, medical, accidental exposures. Evaluation of the effect of low level of neutron exposure to human cells in vitro has important implications to human health. Attempts were made to measure genome damage, transcriptional profile of DNA damage response and repair genes in peripheral blood...
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Ionizing radiations are known to challenge the integrity of the genome, by inducing several lesions like double strand breaks, single strand breaks and oxidative base damages in the DNA. Eukaryotic DNA is packaged inside the nucleus in the form of chromatin, which is formed by the interaction of histone proteins with DNA. Higher order chromatin structure acts as a barrier to the detection and r...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2018
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gey036